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Perhaps one of the hardest working PMO teams of the last 18 months, we kick off the PMO Conference 2021 with an inspirational story. How did the PMO manage to come together to build the wings whilst the plane was flying to support the delivery of the first vaccination in December 2020 and the subsequent millions of vaccinations since? What were the priorities; what were the challenges and the triumphs? What was the technical response of the PMO and how did they support the people and cultural side of such a high profile deployment. How did they fair personally and emotionally – keeping pace with the ups and downs – and what do they think about their part in such a historical event. We hear from two of the central PMO team from the COVID-19 Vaccination Deployment Programme.